Analytical Data
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Gene name
DRD2
- Application
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Alternative Names
Dopamine D2 receptor
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Species
Human
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P14416
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Expression Region
214-373aa
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Molecular Weight
25.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Dopamine D2 receptors (DRD2) play a crucial role in the central nervous system, influencing various physiological functions and behaviors, including motivation, reward processing, and the regulation of mood. Dysregulation of DRD2 signaling has been implicated in several neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and drug addiction. Given its significance, researchers are increasingly focusing on the development of recombinant DRD2 proteins to better understand receptor structure, function, and pharmacology. Recombinant protein expression systems, such as bacteria, yeast, or mammalian cells, allow for the production of large quantities of functional DRD2, facilitating biochemical assays, structural studies, and drug screening applications. Furthermore, these studies can elucidate the receptor's signaling mechanisms, identify potential therapeutic targets, and aid in the design of novel psychotropic medications. Recent advancements in techniques such as X-ray crystallography and cryo-electron microscopy have further propelled the investigation of DRD2, enabling the characterization of its conformational states and interactions with ligands. This research is vital for advancing our understanding of dopamine-related pathways and developing effective treatments for neuropsychiatric disorders.
