Analytical Data
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Gene name
RABGEF1
- Application
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Alternative Names
RAP1Rabaptin-5-associated exchange factor for Rab5Rabex-5
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UJ41
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Expression Region
1-491aa
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Molecular Weight
72.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RABGEF1, a member of the RAB guanine nucleotide exchange factor (GEF) family, plays a crucial role in cellular processes by regulating the activity of RAB GTPases, which are key mediators of intracellular transport and signal transduction. The study of RABGEF1 is particularly relevant in the context of various diseases, including cancer and neurodegenerative disorders, where its dysregulation can disrupt normal cellular functions. Research has demonstrated that RABGEF1 can influence cellular signaling pathways, endocytosis, and exocytosis, thereby affecting cell proliferation, differentiation, and survival. Recent investigations have focused on the mechanisms through which RABGEF1 exerts its effects on RAB proteins, as well as its potential as a therapeutic target. Additionally, understanding the structural and functional characteristics of RABGEF1 through recombinant protein studies could provide valuable insights into its role in health and disease. This research could pave the way for developing novel strategies aimed at modulating RABGEF1 activity to restore normal cellular function in pathological conditions. Thus, RABGEF1 represents a significant focus of study in molecular biology and translational medicine, with promising implications for innovative therapeutic interventions.
