Analytical Data
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Gene name
Menin
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简介
The Menin protein is an important component of the MLL/SET1 HMT complex, which methylates “Lys-4” of histone H3. It acts as a transcriptional regulator, inhibiting telomerase expression and inhibiting cell proliferation through TGFB1. Menin Protein, Human (His, M327V) is the recombinant human-derived Menin, expressed by E. coli, with His labeled tag.
- Application
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Alternative Names
SCG2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00255-1
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Expression Region
M1-L615, M327V
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Protein Length
Full Length of Isoform-1
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Molecular Weight
70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Menin is a protein encoded by the MEN1 gene, which is associated with Multiple Endocrine Neoplasia type 1 (MEN1), a hereditary syndrome characterized by tumors in endocrine glands such as the pituitary, parathyroid, and pancreas. The study of Menin has garnered significant attention due to its crucial role in tumor suppression and regulation of gene expression. Menin functions as a scaffold protein, interacting with various transcription factors and enzymes involved in chromatin remodeling, thereby influencing cell proliferation and differentiation. Research has demonstrated that mutations in the MEN1 gene lead to a loss of Menin function, contributing to the development of neuroendocrine tumors through altered gene regulation and signaling pathways. Furthermore, Menin has been implicated in various biological processes, including cell cycle control, apoptosis, and metabolism. Recent advances in biotechnology have enabled the production of recombinant Menin, facilitating in-depth studies of its structure and function. Understanding the molecular mechanisms underlying Menin’s role in tumorigenesis not only provides insights into the pathology of MEN1 but also holds potential for developing targeted therapies for neuroendocrine tumors. The ongoing exploration of Menin and its interactions continues to illuminate the complexities of endocrine tumorigenesis and may pave the way for novel therapeutic strategies.
