Analytical Data
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Gene name
ABCA12
- Application
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Alternative Names
ABC-A12; LI2; ICR2B; Ichthyosis Congenita II,Lamellar Ichthyosis B; ATP-binding cassette sub-family A member 12
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86UK0
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Expression Region
Val1346~Thr1577
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Molecular Weight
29kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ABCA12 is a member of the ATP-binding cassette (ABC) transporter family, which plays a crucial role in lipid metabolism and cellular homeostasis. It is predominantly expressed in the epidermis and is essential for the formation of the skin barrier. Mutations in the ABCA12 gene are linked to a rare and severe skin disorder called harlequin ichthyosis, characterized by extreme skin dryness and scaling. Researchers have focused on the characterization of ABCA12 recombinant proteins to gain insights into its structure-function relationships and the molecular mechanisms underlying its role in keratinocyte lipid transport and epidermal differentiation. By utilizing various recombinant protein expression systems, scientists aim to produce functional ABCA12 proteins for biochemical and biophysical analysis, which may provide critical information about the domains responsible for substrate binding and transport. Understanding the dynamics of ABCA12 can pave the way for the development of therapeutic strategies for ichthyosis and related skin disorders, as well as advance the broader field of ABC transporter research, highlighting the importance of lipid transport in human health.
