Analytical Data
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基因名
RANTES/CCL5
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简介
RANTES/CCL5 Protein, Human (HEK293) is a key pro-inflammatory chemokine in the CC chemokine family that interacts with CCR1, CCR3, CCR4, and CCR5 to mediate inflammatory immune responses, viral infections, and tumorigenesis. RANTES/CCL5 Protein, Human ( HEK293) is a recombinant human RANTES/CCL5(S24-S91) protein expressed by HEK293[1].
- Application
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别名
rHuRANTES/CCL5; C-C motif chemokine 5; SCYA5
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种属
Human
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表达系统
HEK293
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P13501
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表达区间
S24-S91
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蛋白长度
Full Length of Mature Protein
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分子量
8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RANTES, also known as CCL5 (Regulated upon Activation, Normal T cell Expressed and Secreted), is a crucial chemokine involved in the immune response and inflammation. It primarily functions as a chemoattractant for various immune cells, including T cells, eosinophils, and basophils, influencing their migration and activation during inflammatory and immune reactions. Research into RANTES/CCL5 has gained significant attention due to its role in various pathological conditions, including viral infections, autoimmune diseases, and cancer metastasis. The recombinant production of RANTES/CCL5 has enabled scientists to explore its biological functions, investigate therapeutic applications, and develop potential pharmaceuticals to modulate immune responses. By using techniques such as genetic engineering and protein expression systems, researchers can produce large quantities of this chemokine for detailed studies. These investigations have revealed RANTES/CCL5’s involvement in T cell polarization, its impact on the tissue microenvironment, and its potential as a biomarker for disease progression. Furthermore, understanding the signaling pathways and receptor interactions of RANTES/CCL5 has opened up new avenues for therapeutic interventions in inflammatory diseases and cancer treatment, highlighting its significance as a target in immunotherapy. Consequently, the study of RANTES/CCL5 recombinant protein continues to be a vibrant area of research, promising advancements in both basic biology and clinical applications.
