Analytical Data
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基因名
NR1D1
- Application
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别名
THRA1; EAR1; THRAL; ear-1; hRev; Rev-ErbA Alpha; V-erbA-related protein 1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20393
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表达区间
Met1~Ala325
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分子量
44kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NR1D1, also known as nuclear receptor subfamily 1 group D member 1, is a transcription factor that plays a crucial role in regulating circadian rhythms and metabolic processes. It is involved in the repression of genes associated with inflammation and circadian regulation, thereby influencing various physiological functions. Recent studies have highlighted its significance in energy homeostasis, lipid metabolism, and the modulation of insulin sensitivity. Additionally, NR1D1 has been implicated in various diseases, including metabolic disorders, cardiovascular diseases, and certain cancers. The recombinant protein of NR1D1 serves as an important tool for elucidating its biological functions, helping researchers understand its role in cellular mechanisms and potential therapeutic applications. By overexpressing NR1D1 in various cell models, scientists can investigate its interactions with other proteins, identify target genes, and assess its impact on metabolic signaling pathways. This research is crucial for developing novel strategies to combat metabolic diseases and circadian rhythm-related disorders, highlighting the potential of NR1D1 as a therapeutic target in the field of endocrinology and metabolism.
