Analytical Data
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Gene name
PCDHb14
- Application
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6PB90
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Expression Region
Thr30~Arg189
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Molecular Weight
22kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCDHb14, or protocadherin beta 14, is a member of the protocadherin family, which plays a critical role in the development and function of the nervous system. These proteins are involved in establishing and maintaining synaptic connections and are important for neuronal survival and function. Dysregulation or mutations in protocadherins have been implicated in various neurodevelopmental disorders and neurodegenerative diseases. The research on recombinant PCDHb14 protein primarily focuses on elucidating its structural characteristics, its biochemical properties, and its interactions with other cellular components. Understanding the mechanisms by which PCDHb14 mediates cell-cell adhesion and signal transduction is essential for deciphering its role in neuronal circuitry and its potential contributions to pathologies involving synaptic dysfunction. Studies utilizing recombinant PCDHb14 can provide valuable insights into its functional significance, paving the way for potential therapeutic strategies aimed at targeting specific neurodevelopmental conditions. Moreover, the generation of recombinant PCDHb14 can facilitate the exploration of its potential as a biomarker for neurological disorders, enhancing the development of diagnostic tools. As the field of neurobiology continues to advance, the study of PCDHb14 and its role in synaptic plasticity and connectivity remains a promising area of research.
