Analytical Data
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基因名
TYRO3
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简介
The TYRO3/DTK protein is a tyrosine kinase receptor. TYRO3 transduces signals from the extracellular matrix by activating the PI3K/AKT/ NF-kappa-B pathway. TYRO3 plays an important role in inhibiting Toll-like receptor (TLRs) mediated innate immune response by activating STAT1. TYRO3 has the function of promoting tumor cell survival and/or proliferation, metastasis and chemotherapy resistance. TYRO3/DTK Protein, Human (Q261H, HEK293, Fc) is the recombinant human-derived TYRO3/DTK protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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生物活性
Immobilized TYRO3 at 2 μg/mL (100 μL/well) can bind Biotinylated GAS6 protein. The ED50 for this effect is 161.5 ng/mL, corresponding to a specific activity is 6.19×10^3 Unit/mg. Immobilized TYRO3 at 2 μg/mL (100 μL/well) can bind Biotinylated GAS6 protein. The ED50 for this effect is 161.5 ng/mL, corresponding to a specific activity is 6.19×103 Unit/mg.
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别名
TYRO3; BYK; DTK; RSE; SKY; TIF
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q06418
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表达区间
A41-S428, Q261H
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氨基酸序列
AGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVHVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTS
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蛋白长度
Extracellular Domain
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分子量
85-120 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TYRO3 (Tyrosine-protein kinase receptor TYRO3), a member of the TAM receptor family, plays a crucial role in various physiological processes, including cell survival, proliferation, and immune regulation. It is primarily expressed in the brain, testis, and immune cells, suggesting significant roles in neurology and immunology. Dysregulation or mutations in TYRO3 have been associated with various diseases, including cancer and neurodegenerative disorders, making it a target of interest for therapeutic interventions. Research on TYRO3 recombinant protein has gained traction, as producing this protein in heterologous systems allows for detailed studies of its structure, function, and interactions. These studies are essential for understanding its signaling pathways and potential therapeutic roles. Additionally, the recombinant protein can be used to develop assays and screen for small molecules that modulate its activity. Given the increasing recognition of its importance in health and disease, TYRO3 is positioned as a promising candidate for developing novel diagnostic and therapeutic strategies, making its recombinant protein a valuable tool in biomedical research.
