Analytical Data
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Gene name
TYRO3
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简介
The TYRO3/DTK protein is a tyrosine kinase receptor. TYRO3 transduces signals from the extracellular matrix by activating the PI3K/AKT/ NF-kappa-B pathway. TYRO3 plays an important role in inhibiting Toll-like receptor (TLRs) mediated innate immune response by activating STAT1. TYRO3 has the function of promoting tumor cell survival and/or proliferation, metastasis and chemotherapy resistance. TYRO3/DTK Protein, Human (Q261H, HEK293, Fc) is the recombinant human-derived TYRO3/DTK protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Biological Activity
Immobilized TYRO3 at 2 μg/mL (100 μL/well) can bind Biotinylated GAS6 protein. The ED50 for this effect is 161.5 ng/mL, corresponding to a specific activity is 6.19×10^3 Unit/mg. Immobilized TYRO3 at 2 μg/mL (100 μL/well) can bind Biotinylated GAS6 protein. The ED50 for this effect is 161.5 ng/mL, corresponding to a specific activity is 6.19×103 Unit/mg.
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Alternative Names
TYRO3; BYK; DTK; RSE; SKY; TIF
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q06418
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Expression Region
A41-S428, Q261H
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AA Sequence
AGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVHVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTS
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Protein Length
Extracellular Domain
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Molecular Weight
85-120 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TYRO3 (Tyrosine-protein kinase receptor TYRO3), a member of the TAM receptor family, plays a crucial role in various physiological processes, including cell survival, proliferation, and immune regulation. It is primarily expressed in the brain, testis, and immune cells, suggesting significant roles in neurology and immunology. Dysregulation or mutations in TYRO3 have been associated with various diseases, including cancer and neurodegenerative disorders, making it a target of interest for therapeutic interventions. Research on TYRO3 recombinant protein has gained traction, as producing this protein in heterologous systems allows for detailed studies of its structure, function, and interactions. These studies are essential for understanding its signaling pathways and potential therapeutic roles. Additionally, the recombinant protein can be used to develop assays and screen for small molecules that modulate its activity. Given the increasing recognition of its importance in health and disease, TYRO3 is positioned as a promising candidate for developing novel diagnostic and therapeutic strategies, making its recombinant protein a valuable tool in biomedical research.
