Analytical Data
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Gene name
CDK11B
- Application
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Alternative Names
CDC2L1; CDK11; PITSLREA; PK58; Cell division cycle 2-like kinase 1; PITSLRE serine/threonine-protein kinase CDC2L1; Galactosyltransferase-associated protein kinase p58/GTA
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P21127
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Expression Region
Phe438~Arg724
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Molecular Weight
37kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CDK11B (Cyclin-dependent kinase 11B) is a crucial component of the cell cycle regulation and is involved in various cellular processes, including RNA splicing, transcription, and apoptosis. As a member of the cyclin-dependent kinase family, CDK11B plays a vital role in the phosphorylation of serine and threonine residues on target proteins, thus influencing cell cycle progression and gene expression. Research has shown that CDK11B is implicated in several diseases, including cancer, where its dysregulation can lead to uncontrolled cell proliferation. Additionally, it has been recognized for its potential as a therapeutic target, making the understanding of its structure and function increasingly important. The study of CDK11B recombinant proteins allows researchers to investigate its enzymatic activity, interaction with cyclins, and the downstream effects on cellular pathways. By generating CDK11B in a recombinant format, scientists can explore its role in various biological contexts, contributing to better insights into its mechanism of action and opening avenues for novel treatments targeting CDK11B-related pathways in diseases.
