Analytical Data
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Gene name
CDK14
- Application
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Alternative Names
PFTK1; PFTAIRE1; Serine/Threonine-Protein Kinase PFTAIRE-1; Cell division protein kinase 14
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O94921
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Expression Region
Tyr135~Phe419
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Molecular Weight
36kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK14 (cyclin-dependent kinase 14) is a relatively understudied member of the cyclin-dependent kinase family, which plays a crucial role in cell cycle regulation and transcriptional control. Recent research has highlighted its involvement in key cellular processes, including RNA splicing, transcriptional regulation, and cell proliferation, making it a protein of significant interest in cancer biology and other diseases. CDK14 functions through its association with cyclins, particularly cyclin Y, forming an active complex that influences the activity of various substrates, including RNA polymerase II. Aberrant expression and activity of CDK14 have been linked to oncogenic transformation and tumor progression, suggesting that it may serve as a potential therapeutic target. Additionally, the understanding of CDK14's mechanisms of action and its interaction with other cellular pathways can offer insights into the development of novel treatment strategies. To study CDK14's role in cellular processes, researchers have focused on the use of recombinant CDK14 protein, allowing for detailed biochemical analyses and functional assays. The generation of a high-purity, active form of CDK14 provides a platform for investigating its catalytic functions, substrate specificity, and regulatory mechanisms. Such studies aim to elucidate the intricacies of CDK14's role in cell cycle regulation and its impact on tumorigenesis, paving the way toward targeted therapies that may inhibit its activity in cancer cells, ultimately contributing to the development of more effective cancer treatments.
