Analytical Data
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Gene name
MCM5
- Application
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Alternative Names
CDC46; P1-CDC46; Cell Division Cycle 46; DNA replication licensing factor MCM5
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P33992
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Expression Region
Val331~Ile537
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Molecular Weight
26kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MCM5 (minichromosome maintenance 5) is a vital member of the MCM protein family, which plays a crucial role in DNA replication and the maintenance of genomic stability. As part of the MCM complex, MCM5 functions as a helicase, unwinding DNA strands during the replication process, thereby facilitating the accurate duplication of genetic material. Dysregulation of MCM5 expression has been implicated in various cancers, making it a potential biomarker and therapeutic target in oncology. Research on MCM5 recombinant proteins has gained traction, aiming to elucidate its molecular mechanisms and interactions within the cell cycle, particularly in the initiation of DNA replication. By using techniques such as recombinant DNA technology, scientists can produce MCM5 in a laboratory setting, allowing for detailed biochemical characterization and structural studies. Understanding how MCM5 operates within the MCM complex not only sheds light on fundamental cellular processes but also opens avenues for developing targeted therapies that inhibit its activity in cancerous cells. The exploration of MCM5’s role in DNA replication dynamics also raises important questions about its involvement in other cellular functions, potentially linking it to broader aspects of cell biology and disease. Overall, the research on MCM5 recombinant protein presents a promising field with significant implications for cancer therapy and our understanding of cell cycle regulation.
