Analytical Data
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Gene name
GBP7
- Application
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Alternative Names
GBP4L; GTP-binding protein 7; Guanine nucleotide-binding protein 7; Guanylate-binding protein 4-like
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N8V2
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Expression Region
Thr35~Lys277
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Molecular Weight
32kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The GBP7 protein, a member of the guanylate-binding protein (GBP) family, is an important component of the immune response, particularly in the context of antiviral defense mechanisms. Research into GBP7 has gained traction due to its potential role in modulating the host's immune response to various pathogens, including viruses and intracellular bacteria. GBP proteins are known to possess GTPase activity and are involved in the regulation of inflammatory responses, cellular signaling, and apoptosis. The study of GBP7 is crucial for understanding how it contributes to the innate immune response, particularly in promoting the clearance of intracellular pathogens. Recent studies have suggested that GBP7 may play a role in autophagy and the recruitment of immune cells to sites of infection, thus highlighting its potential as a therapeutic target for enhancing immune responses. Furthermore, investigations into GBP7 also explore its interactions with other proteins and pathways involved in immune regulation, providing insights into the complex network of host-pathogen interactions. As such, GBP7 serves as an intriguing subject for research aimed at developing novel strategies for immunomodulation, particularly in the face of emerging infectious diseases and antimicrobial resistance.
