Analytical Data
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基因名
CDC16
- Application
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别名
APC6; ANAPC6; Anaphase-Promoting Complex Subunit 6; Cyclosome subunit 6
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13042
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表达区间
Met1~Ser152
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分子量
22kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDC16 is a crucial component of the anaphase-promoting complex/cyclosome (APC/C), a multi-subunit E3 ubiquitin ligase that plays a pivotal role in regulating the cell cycle. As a part of the APC/C complex, CDC16 is involved in the timely degradation of cell cycle regulators, including cyclins and securin, which are essential for proper progression through mitosis and ensuring genomic stability. Dysregulation of CDC16 has been associated with various cancers and other diseases, underscoring its importance in maintaining cellular homeostasis. Research into CDC16, particularly in the context of its role in the APC/C function, has gained momentum as scientists aim to uncover its mechanistic details and interactions with other cellular components. This research is critical not only for understanding fundamental cell cycle dynamics but also for identifying potential therapeutic targets in cancer treatment, where aberrant cell cycle regulation is a hallmark. Studies have employed biochemical assays, structural biology techniques, and cellular models to investigate the function and regulation of CDC16, revealing insights into its role in ubiquitin-mediated proteolysis and genetic stability during cell division. As a result, CDC16 represents a significant focus in cell biology and cancer research, highlighting the intricate balance of proteins that govern cell division and their implications in disease.
