Analytical Data
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Gene name
CDC16
- Application
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Alternative Names
APC6; ANAPC6; Anaphase-Promoting Complex Subunit 6; Cyclosome subunit 6
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13042
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Expression Region
Met1~Ser152
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Molecular Weight
22kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CDC16 is a crucial component of the anaphase-promoting complex/cyclosome (APC/C), a multi-subunit E3 ubiquitin ligase that plays a pivotal role in regulating the cell cycle. As a part of the APC/C complex, CDC16 is involved in the timely degradation of cell cycle regulators, including cyclins and securin, which are essential for proper progression through mitosis and ensuring genomic stability. Dysregulation of CDC16 has been associated with various cancers and other diseases, underscoring its importance in maintaining cellular homeostasis. Research into CDC16, particularly in the context of its role in the APC/C function, has gained momentum as scientists aim to uncover its mechanistic details and interactions with other cellular components. This research is critical not only for understanding fundamental cell cycle dynamics but also for identifying potential therapeutic targets in cancer treatment, where aberrant cell cycle regulation is a hallmark. Studies have employed biochemical assays, structural biology techniques, and cellular models to investigate the function and regulation of CDC16, revealing insights into its role in ubiquitin-mediated proteolysis and genetic stability during cell division. As a result, CDC16 represents a significant focus in cell biology and cancer research, highlighting the intricate balance of proteins that govern cell division and their implications in disease.
