Analytical Data
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Gene name
XPA
- Application
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Alternative Names
XP-A; XPAC; XP1; DNA repair protein complementing XP-A cells
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P23025
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Expression Region
Ser23~Glu271
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Molecular Weight
60kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
XPA, or Xeroderma Pigmentosum group A protein, is a crucial component of the nucleotide excision repair (NER) pathway, which is responsible for removing DNA lesions caused by environmental factors such as UV radiation and chemical exposure. Deficiencies in XPA lead to xeroderma pigmentosum, a rare genetic disorder characterized by extreme sensitivity to sunlight and a heightened risk of skin cancers due to the inability to effectively repair DNA damage. Research on XPA recombinant protein has gained significant attention as it allows for the detailed study of its structure, function, and interactions with other proteins involved in the NER pathway. Such studies have been instrumental in elucidating the molecular mechanisms underlying DNA repair and the biological implications of XPA mutations. Furthermore, producing XPA in recombinant form enables researchers to investigate potential therapeutic interventions and enhance our understanding of cancer prevention strategies. As a model system for studying DNA repair processes, the recombinant XPA protein provides invaluable insights into the complex interactions within the NER pathway and offers potential avenues for the development of gene-targeted therapies, thereby addressing both fundamental biological questions and practical applications in medicine.
