Analytical Data
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Gene name
TJP2
- Application
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Alternative Names
X104; ZO-2; ZO2; Zona Occludens 2; Friedreich Ataxia Region Gene X104; Zona occludens protein 2; Zonula occludens protein 2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UDY2
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Expression Region
Gly307~Ala669
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Molecular Weight
49kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TJP2, also known as tight junction protein 2, is a key member of the tight junction protein family, playing a critical role in maintaining the integrity of epithelial and endothelial cell barriers. It is integral to the formation of tight junctions, which regulate paracellular transport and help maintain homeostasis in various tissues. Dysfunction in TJP2 has been implicated in a range of pathological conditions, including cancer, inflammatory diseases, and neurological disorders. Research into TJP2 has grown significantly as scientists seek to understand its molecular mechanisms and interactions, particularly in relation to cell signaling pathways and permeability. Recombinant TJP2 protein studies have become essential for elucidating its structural properties, functional roles, and potential as a biomarker or therapeutic target. The availability of purified recombinant TJP2 facilitates investigations into its interactions with other proteins and cellular components, enabling researchers to determine how alterations in TJP2 expression or function might contribute to disease processes. Ultimately, understanding TJP2 could lead to novel strategies for managing diseases associated with tight junction dysfunction, highlighting the importance of continued research in this area.
