Analytical Data
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Gene name
DAPK3
- Application
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Alternative Names
ZIP; ZIPK; Dlk; DAP-like kinase; MYPT1 kinase; Zipper-interacting protein kinase
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O54784
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Expression Region
Met1~Arg448
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Molecular Weight
55kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DAPK3, or Death-Associated Protein Kinase 3, is a serine/threonine kinase that plays a significant role in various cellular processes, including apoptosis, autophagy, and cell differentiation. Its dysregulation has been implicated in several pathological conditions, such as cancer and neurodegenerative diseases, making it a target of interest for therapeutic development. Research has shown that DAPK3 can modulate signaling pathways associated with cell survival and death, suggesting its potential as a biomarker for disease progression and treatment response. Recent advancements in recombinant protein technology have enabled the production of DAPK3 in a more stable and active form, facilitating in-depth structural and functional studies. These studies aim to elucidate the mechanisms by which DAPK3 exerts its effects within the cell, identify potential interacting proteins, and explore its post-translational modifications. Understanding the biological role of DAPK3 through recombinant protein studies is crucial for developing novel therapeutic strategies that can mitigate its aberrant activity in diseases. As researchers continue to investigate the functional implications of DAPK3, it holds promise for contributing to the development of targeted therapies, ultimately improving patient outcomes in disorders where this kinase plays a critical role.
