Analytical Data
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基因名
EPB49
- Application
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别名
DMT; DMTN; Dematin; Dematin actin-binding protein
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q08495
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表达区间
Met1~Ser269
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分子量
34kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EPB49, also known as erythrocyte membrane protein Band 4.9, is a crucial member of the spectrin-associated protein family that plays a significant role in maintaining the structural integrity and functionality of the erythrocyte membrane. This protein is encoded by the EPB49 gene, located on human chromosome 1. Research has shown that EPB49 interacts with spectrin and other cytoskeletal proteins, contributing to the elasticity and stability of red blood cells. Abnormalities in EPB49 expression or function can lead to various hematological disorders, including hereditary spherocytosis, a condition characterized by spherical-shaped red blood cells that are prone to hemolysis. Given its vital role in red blood cell biology, EPB49 has garnered attention in studies related to anemia, cell membrane dynamics, and the mechanisms underlying certain blood disorders. Furthermore, understanding the molecular and functional aspects of EPB49 has implications for developing therapeutic strategies, particularly in enhancing red blood cell stability and function in clinical settings. As research progresses, the exploration of EPB49's interactions at the molecular level, its regulatory mechanisms, and its potential as a biomarker for diseases will be instrumental in advancing our knowledge of erythrocyte biology and the pathology of blood-related disorders.
