Analytical Data
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基因名
DRD2
- Application
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别名
DRD2; D(2 dopamine receptor; Dopamine D2 receptor
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种属
Human
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表达系统
E. coli
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标签
N-10*His;C-Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P14416
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表达区间
I214-Q373
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蛋白长度
Cytoplasmic Domain
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分子量
33 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Dopamine D2 receptors (DRD2) play a crucial role in the central nervous system, influencing various physiological functions and behaviors, including motivation, reward processing, and the regulation of mood. Dysregulation of DRD2 signaling has been implicated in several neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and drug addiction. Given its significance, researchers are increasingly focusing on the development of recombinant DRD2 proteins to better understand receptor structure, function, and pharmacology. Recombinant protein expression systems, such as bacteria, yeast, or mammalian cells, allow for the production of large quantities of functional DRD2, facilitating biochemical assays, structural studies, and drug screening applications. Furthermore, these studies can elucidate the receptor's signaling mechanisms, identify potential therapeutic targets, and aid in the design of novel psychotropic medications. Recent advancements in techniques such as X-ray crystallography and cryo-electron microscopy have further propelled the investigation of DRD2, enabling the characterization of its conformational states and interactions with ligands. This research is vital for advancing our understanding of dopamine-related pathways and developing effective treatments for neuropsychiatric disorders.
