Analytical Data
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Gene name
HDAC6
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简介
The HDAC6 protein coordinates multiple functions, deacetylating histones and proteins such as tubulin and CTTN. Its role in epigenetic repression affects transcription, cell cycle, and development. HDAC6 Protein, Human (sf9, His) is the recombinant human-derived HDAC6 protein, expressed by Sf9 insect cells, with C-8*His labeled tag.
- Application
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Species
Human
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Source
Baculovirus
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UBN7-1
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Expression Region
T2-H1215
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Protein Length
Partial
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Molecular Weight
130 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family, notable for its dual function as both a histone deacetylase and a cytoplasmic enzyme involved in various non-histone protein deacetylation processes. This enzyme primarily localizes in the cytoplasm, where it plays critical roles in regulating cellular functions such as protein degradation, cell migration, and immune responses. HDAC6 has been implicated in several diseases, including cancer, neurodegenerative disorders, and inflammation, making it a promising therapeutic target. Recent studies have highlighted its role in the acetylation status of key proteins involved in microtubule dynamics, such as tubulin and Hsp90, which are crucial for cellular homeostasis. The ability of HDAC6 to regulate the acetylation of non-histone substrates has spurred interest in developing small-molecule inhibitors that could selectively target HDAC6 for potential therapeutic applications. Understanding the structural and functional properties of HDAC6 through recombinant protein studies is vital for elucidating its mechanisms of action and for the design of effective HDAC6 modulators. Thus, research into HDAC6 recombinant proteins not only enhances our knowledge of its biological functions but also paves the way for innovative strategies to combat diseases associated with dysregulated HDAC6 activity.
