Recombinant Mouse CLDN2 Protein，His & SUMO

CLDN2, or Claudin-2, is a member of the claudin family of tight junction proteins, which play a crucial role in maintaining the integrity of epithelial and endothelial barriers. These proteins regulate paracellular permeability and are essential for various physiological processes, including ion transport and tissue homeostasis. Unlike other claudins, CLDN2 is known to form channels that allow selective permeability, particularly for cations. Its expression is upregulated in various pathological conditions, including inflammatory bowel disease (IBD) and certain cancers, indicating its involvement in disease progression and tissue remodeling. Researchers are increasingly focused on CLDN2 due to its dual role as a tight junction protein and a potential therapeutic target. Understanding its structure and function can provide insights into the mechanisms underlying barrier dysfunction in diseases characterized by increased permeability. Recent studies have utilized recombinant CLDN2 proteins to investigate their properties, such as channel conductance and interaction with other tight junction components. The characterization of CLDN2 at the molecular level will enhance our understanding of tight junction dynamics and facilitate the development of targeted therapies aimed at restoring barrier function in affected tissues. Overall, CLDN2's significance in both normal physiology and disease pathogenesis makes it a vital subject of research in the field of cell biology and medicine.