Analytical Data
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Gene name
Cadherin-1/CD324
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简介
The Cadherin-1/CD324 protein is a calcium-dependent receptor on myeloid cells that binds to carbohydrates on neutrophils and monocytes. It promotes interactions between activated endothelial cells or platelets and leukocytes. Cadherin-1/CD324 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Cadherin-1/CD324 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Cadherin-1; Cadherin1; E-Cadherin; E Cadherin; Epithelial cadherin; CDH1; CD324; Arc-1; CAD1; ECAD; E-CAD; LCAM; UVO; L-CAM;
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Species
Cynomolgus
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A0A2K5V299
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Expression Region
D155-P708
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Protein Length
Partial
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Molecular Weight
68-78 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cadherin-1 (CD324) is a critical cell adhesion molecule belonging to the cadherin family, known for its role in mediating intercellular adhesion and maintaining tissue integrity. This protein is primarily expressed in epithelial tissues and is crucial for processes such as embryogenesis, tissue morphogenesis, and wound healing. Dysregulation of CD324 has been implicated in various pathological conditions, including cancer progression, where it can influence tumor invasion and metastasis by altering cell-cell interactions. Research has increasingly focused on the production of recombinant CD324 protein to study its adhesive properties and molecular mechanisms. By using techniques such as recombinant DNA technology, scientists can produce large quantities of CD324, facilitating detailed investigations into its structure-function relationships. Understanding the role of CD324 in cellular behavior not only provides insights into fundamental biological processes but also holds potential for therapeutic applications, such as the development of strategies to target and modulate cancer metastasis through modulation of cell adhesion pathways. Additionally, studying CD324's interactions with other proteins may reveal novel targets for drug development and biomarker identification in cancer diagnostics. Overall, recombinant CD324 serves as a valuable tool for advancing our knowledge of cell adhesion mechanisms and their implications in health and disease.
