Analytical Data
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基因名
Cadherin-3
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简介
Cadherin-3 Protein, Human (630a.a, HEK293, His) is a recombinant human Cadherin-3 (P-cadherin) produced in HEK293 cells, with His tag. Cadherin-3 is a classical cell-to-cell adhesion molecule with a homeostatic function in several normal tissues[1].
- Application
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别名
rHuCadherin-3, His; Cadherin-3; Placental Cadherin; CDH3;
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
AAH41846.1
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表达区间
E25-G654
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氨基酸序列
EPCRAVFREAEVTLEAGGAEQEPGQALGKVFMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIFPSKRILRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTVIRATVCDCHGHVETCPGPWKGGHHHHHH
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蛋白长度
Partial
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分子量
88-110 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cadherin-3, also known as P-cadherin, is a member of the cadherin family of proteins, which are essential for cellular adhesion and tissue morphogenesis. This protein plays a critical role in maintaining the structural integrity of tissues and mediating cell-cell interactions. Research has shown that Cadherin-3 is involved in various physiological processes, including embryonic development and tissue patterning. It is primarily expressed in epithelial tissues and has been implicated in the progression of certain cancers, particularly in promoting epithelial-mesenchymal transition (EMT), a key process that facilitates tumor invasion and metastasis. Understanding the structure and function of Cadherin-3, particularly through the study of recombinant proteins, is crucial for elucidating its role in disease states and development. Recombinant Cadherin-3 proteins can be generated for various applications, such as studying binding affinities, elucidating signaling pathways, and exploring potential therapeutic targets. Additionally, the study of Cadherin-3 offers insights into the mechanisms of cell adhesion and differentiation, making it a significant focus for research in developmental biology and cancer therapeutics. Given its relevance, ongoing investigations aim to characterize Cadherin-3 interactions at the molecular level, assess its expression patterns under physiological and pathological conditions, and evaluate its potential as a biomarker for cancer diagnosis and prognosis.
