Analytical Data
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Gene name
AP4s1
- Application
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Alternative Names
CLA20; AP47B; Sigma-4-adaptin
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y587
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Expression Region
Met1~Ser144
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Molecular Weight
18kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
AP4s1 is a significant protein that plays a crucial role in various biological processes, particularly in the context of cellular transport and signaling. Research surrounding AP4s1 focuses on its function within the AP-4 (Adaptor Protein complex 4) system, which is essential for sorting proteins into the appropriate vesicles for transport within cells, especially in neurons. Mutations in the AP4s1 gene have been linked to genetic disorders, including intellectual disabilities and developmental issues, emphasizing the need for a deeper understanding of its mechanisms. Recent studies have explored the structure and interactions of AP4s1, revealing its importance in the recruitment of cargo molecules and the regulation of synaptic functions. Investigating the pathways involving AP4s1 offers valuable insights into the pathophysiology of related diseases, and potential therapeutic strategies. The ongoing research aims to unravel the complex network of interactions involving AP4s1 and its impact on cellular homeostasis and neurodevelopment, ultimately hoping to inform treatment approaches for disorders associated with its dysfunction.
