Analytical Data
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Gene name
Cadherin-8
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简介
Cadherin-8, a calcium-dependent cell adhesion protein, participates in homophilic interactions, potentially aiding the sorting of diverse cell types. Its ability for preferential homophilic interaction underscores its role in mediating cell-cell adhesions and implies involvement in cellular organization and coordination. Cadherin-8 Protein, Rat (HEK293, His) is the recombinant rat-derived Cadherin-8 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Cadherin8; CDH8; Nbla04261
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Species
Rat
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
NP_445845.2
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Expression Region
A30-M621
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Protein Length
Partial
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Molecular Weight
75-85 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cadherin-8 is a member of the cadherin superfamily, which plays a crucial role in cell-cell adhesion and is fundamental for tissue development, organization, and homeostasis. It is primarily expressed in the brain, particularly in neurons, where it influences synaptic formation and stability, impacting processes such as learning and memory. Research has shown that cadherins, including Cadherin-8, are involved in various neurological disorders, highlighting their potential as therapeutic targets. Despite its importance, the functional mechanisms of Cadherin-8 remain underexplored due to challenges in studying its structure and interactions in living systems. The development of recombinant Cadherin-8 proteins enables researchers to investigate its properties and biological roles effectively. By utilizing advanced techniques such as protein engineering and structural biology, scientists aim to unravel the intricate pathways mediated by Cadherin-8 in neuronal connectivity and signal transduction. Ultimately, this research holds promise not only for understanding fundamental biological processes but also for advancing therapeutic strategies for neurological diseases associated with cadherin dysfunction.
