Analytical Data
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基因名
STAG2
- Application
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别名
SA2; Cohesin subunit SA-2; SCC3 homolog 2
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N3U4
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表达区间
Met1~Leu268
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分子量
38kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STAG2 is a protein that plays a critical role in the cohesion of sister chromatids during cell division, specifically in the mitotic and meiotic processes. It is a fundamental component of the cohesion complex, which ensures accurate chromosome segregation. Abnormalities in STAG2 have been linked to various cancers, particularly in hematological malignancies. Research has shown that mutations and deletions of the STAG2 gene can lead to genomic instability, a hallmark of many tumors. Furthermore, the loss of STAG2 function is associated with poor prognosis in certain cancers, highlighting its potential role as a tumor suppressor. As a result, the study of STAG2, including the generation of recombinant STAG2 proteins, has become pivotal for understanding its mechanisms in chromosomal stability and its implications in cancer biology. The production of recombinant STAG2 proteins allows researchers to investigate the structure-function relationships of this protein, assess its interactions with other cellular components, and explore its potential as a therapeutic target. Overall, ongoing research into STAG2 is essential for uncovering the intricacies of chromosomal cohesion and the implications of its dysregulation in cancer progression.
