Analytical Data
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Gene name
STAG2
- Application
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Alternative Names
SA2; Cohesin subunit SA-2; SCC3 homolog 2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N3U4
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Expression Region
Met1~Leu268
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Molecular Weight
38kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STAG2 is a protein that plays a critical role in the cohesion of sister chromatids during cell division, specifically in the mitotic and meiotic processes. It is a fundamental component of the cohesion complex, which ensures accurate chromosome segregation. Abnormalities in STAG2 have been linked to various cancers, particularly in hematological malignancies. Research has shown that mutations and deletions of the STAG2 gene can lead to genomic instability, a hallmark of many tumors. Furthermore, the loss of STAG2 function is associated with poor prognosis in certain cancers, highlighting its potential role as a tumor suppressor. As a result, the study of STAG2, including the generation of recombinant STAG2 proteins, has become pivotal for understanding its mechanisms in chromosomal stability and its implications in cancer biology. The production of recombinant STAG2 proteins allows researchers to investigate the structure-function relationships of this protein, assess its interactions with other cellular components, and explore its potential as a therapeutic target. Overall, ongoing research into STAG2 is essential for uncovering the intricacies of chromosomal cohesion and the implications of its dysregulation in cancer progression.
