Analytical Data
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Gene name
DSG2/Desmoglein-2
- Application
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Alternative Names
(Cadherin family member 5)(HDGC)
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14126
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Expression Region
50-609aa
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Molecular Weight
68.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Desmoglein-2 (DSG2) is a critical component of intercellular adhesion in epithelial tissues, functioning as a part of desmosomes that maintain cell integrity and tissue architecture. The study of recombinant DSG2 has gained prominence due to its significant role in both health and disease, particularly in conditions such as pemphigus vulgaris and other autoimmune disorders where desmosome integrity is compromised. Understanding DSG2's structure and function at a molecular level is essential for elucidating the mechanisms underlying these diseases. Recombinant DSG2 proteins can be used in various research applications, including the development of diagnostic tools and therapeutic strategies aimed at modulating cell adhesion and restoring tissue integrity. The ability to produce DSG2 in a recombinant form allows for in-depth studies on its interactions with other cellular components, the impact of specific mutations, and the development of targeted therapies. This research not only enhances our understanding of desmosomal biology but also opens new avenues for treating diseases related to desmosomal dysfunction.
