Analytical Data
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基因名
TARC/CCL17
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简介
CCL17 protein is a chemokine with selective chemotactic activity towards Th2 cells and plays a crucial role in various inflammatory and immune processes. It coordinates immune responses by binding to CCR4 on the surface of T cells. TARC/CCL17 Protein, Rat (His) is the recombinant rat-derived TARC/CCL17 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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生物活性
1.Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10 ng/mL. 2.Measured by its ability to chemoattract Jurkat cells. The ED50 for this effect is approximately 0.6155 ng/mL, corresponding to a specific activity is 1.62×106 U/mg. Measured by its ability to chemoattract Jurkat cells. The ED50 for this effect is approximately 0.6155 ng/mL, corresponding to a specific activity is 1.62×106 U/mg.
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别名
C-C motif chemokine; CCL17
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种属
Rat
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表达系统
E. coli
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标签
N-6*His
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纯度
Measured by its ability to chemoattract Jurkat cells. The ED50 for this effect is approximately 0.6155 ng/mL, corresponding to a specific activity is 1.62×106 U/mg.
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蛋白编号
Q9ERE0
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表达区间
A24-L93
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蛋白长度
Full Length of Mature Protein
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分子量
12 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TARC (Thymus and Activation-Regulated Chemokine) and CCL17 are chemokines belonging to the CC chemokine family, primarily involved in immune responses, notably in the recruitment of T cells and other immune cells to sites of inflammation. Research on TARC/CCL17 has gained prominence due to its significant role in various allergic and autoimmune diseases, such as asthma, atopic dermatitis, and psoriasis. Elevated levels of TARC/CCL17 have been correlated with the severity of these conditions, making it a potential biomarker for disease progression and treatment efficacy. Furthermore, its interaction with specific receptors, such as CCR4, highlights its importance in mediating immune cell migration. The development of recombinant TARC/CCL17 proteins facilitates the exploration of their biological functions, receptor interactions, and potential therapeutic applications. These proteins can be utilized in in vitro studies to understand their roles in immune modulation and inflammation. Additionally, they hold promise for the development of targeted therapies aimed at manipulating the immune response in allergic and autoimmune disorders. Overall, TARC/CCL17 recombinant protein research is essential for understanding immune mechanisms and exploring new avenues for treatment.
