Analytical Data
-
基因名
WNK1
- Application
-
别名
HSN2; KDP; PHA2C; PRKWNK1; HSAN2; Protein Kinase,Lysine Deficient 1; Hereditary Sensory Neuropathy, Type II; Erythrocyte 65 kDa protein; Kinase deficient protein
-
种属
Human
-
表达系统
E. coli
-
标签
N-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9H4A3
-
表达区间
Lys1954~Ala2231
-
分子量
40kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
WNK1 (With No K (Lys) 1) is a serine/threonine kinase that plays a critical role in regulating various physiological processes, including blood pressure and ion homeostasis. Dysregulation of WNK1 has been associated with several pathological conditions, such as hypertension and genetic disorders like pseudohypoaldosteronism type II. This has spurred significant interest in understanding the structure, function, and mechanisms of action of WNK1. Research into recombinant WNK1 proteins has gained traction as scientists aim to decipher its signaling pathways and interactions with other cellular components. The production of WNK1 recombinant protein allows for in-depth investigations into its enzymatic activity, regulatory mechanisms, and potential as a therapeutic target. Moreover, studies utilizing WNK1 recombinant constructs facilitate the exploration of its role in cellular responses to stress and its implications in disease contexts, providing insights that could lead to novel interventions. By characterizing WNK1 at a molecular level, researchers are equipped to develop targeted therapies that may mitigate the effects of WNK1 dysregulation, thus enhancing our understanding of cardiovascular health and related disorders.
