Analytical Data
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Gene name
SETBP1
- Application
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Alternative Names
SEB
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y6X0
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Expression Region
Gly1297~Pro1596
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Molecular Weight
55kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SETBP1 (SET Binding Protein 1) is a gene located on chromosome 18 that encodes a protein involved in various cellular processes, including transcription regulation and chromatin remodeling. Recent studies have highlighted its significant role in both normal development and pathological conditions, particularly in myeloid malignancies like chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). Mutations in SETBP1 are increasingly recognized as potential driver mutations that contribute to the development and progression of these cancers. The presence of SETBP1 mutations is associated with poor prognosis and increased treatment resistance, underscoring the need for further research into its functional implications. Given its critical involvement in hematopoiesis and leukemogenesis, the recombinant expression of SETBP1 protein is essential for understanding its biochemical properties and interactions with other cellular factors. Through the generation of recombinant SETBP1 protein, researchers aim to elucidate its mechanisms of action, identify potential interacting partners, and explore its role as a therapeutic target. This work has the potential to provide valuable insights into the molecular underpinnings of SETBP1-related disorders, paving the way for the development of novel therapeutic strategies aimed at targeting its dysregulation in disease contexts.
