Analytical Data
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基因名
E2F2
- Application
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14209
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表达区间
Arg129~Tyr429
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分子量
68kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
E2F2, a member of the E2F transcription factor family, plays a critical role in regulating the cell cycle and is involved in the transcriptional activation of genes necessary for DNA synthesis and progression through the S phase. Research on E2F2 is particularly significant due to its dual function in promoting cell proliferation and its potential involvement in tumorigenesis. Dysregulation of E2F2 has been linked to various cancers, making it an interesting target for cancer therapy. Studies have shown that E2F2 can interact with other proteins and transcription factors, such as retinoblastoma (Rb) protein, which modulates its activity and stability. Furthermore, E2F2 not only participates in the control of cell cycle progression but also has implications in developmental processes and cellular differentiation. This multifaceted role suggests that understanding the mechanisms governing E2F2 function and regulation could provide insights into both normal cellular processes and pathological conditions. Ongoing research aims to elucidate the precise signaling pathways that regulate E2F2 activity and to explore its potential as a biomarker or therapeutic target in cancer treatment. Overall, the study of E2F2 is crucial for advancing our knowledge of cell cycle regulation, cancer biology, and potential therapeutic interventions.
