Analytical Data
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基因名
Integrin alpha V beta 8
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简介
Integrin alpha V beta 3 (ITGAV:ITGB3) functions as a receptor for CD40LG, enhancing Lilrb4a inhibitory effects on mast cell activation. It suppresses marginal zone B cell antibody production through Lilrb4a interaction. ITGAV:ITGB3, forming a heterodimer with ITGAV, interacts with ligands such as RAB25, CIB1, FBLN5, and more. It also forms a complex with PTPRZ1 and PTN, stimulating endothelial cell migration. Integrin alpha V beta 8 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 8 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha V beta 8 Protein, Mouse (HEK293, His), has molecular weight of 80-140 kDa.
- Application
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别名
αVβ8; Integrin alpha V beta 8; ITGAV&ITGB8; Integrin alpha V β 8
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种属
Mouse
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P43406 (F31-V988)&Q0VBD0
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表达区间
P43406 (F31-V988)&Q0VBD0 (G22-S679)
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分子量
80-140 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Integrin alpha V beta 8 is a heterodimeric cell adhesion receptor that plays a significant role in various biological processes, including cell migration, proliferation, and differentiation. It is primarily involved in the interactions between cells and the extracellular matrix, which are crucial for tissue development and immune responses. The integrin is expressed in several cell types, including epithelial cells, immune cells, and certain tumor cells, suggesting its potential importance in both physiological and pathological contexts. Recent studies have highlighted its involvement in cancer progression, particularly in the tumor microenvironment, where it may facilitate the invasion and metastasis of cancer cells. Furthermore, integrin alpha V beta 8 has been implicated in regulating immune responses, particularly in the context of T cell activation and polarization. As a result, this integrin has emerged as a promising target for therapeutic interventions in cancer and autoimmune diseases. Researchers are increasingly focusing on producing recombinant forms of integrin alpha V beta 8 to better understand its structure-function relationships and to investigate its potential as a biomarker or therapeutic target. Recombinant proteins can be utilized in a variety of experimental settings, including binding assays, functional studies, and development of inhibitors, paving the way for novel treatment strategies aimed at modulating integrin-mediated processes in disease. Thus, the study of integrin alpha V beta 8 not only sheds light on fundamental biological mechanisms but also opens up avenues for innovative clinical applications in treating various diseases.
