Analytical Data
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基因名
ETV5
- Application
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别名
ERM; Ets-Related Molecule; ETS translocation variant 5
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种属
Human
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表达系统
E. coli
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标签
Two N- s, His- & SUMO-
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P41161
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表达区间
Ser242~Tyr510
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分子量
50kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ETV5, a member of the Ets transcription factor family, has garnered significant attention in recent years due to its role in various biological processes and its implications in cancer. Initially studied for its involvement in developmental processes, ETV5 has been identified as a key player in cell proliferation, differentiation, and survival. Importantly, the dysregulation of ETV5 expression has been linked to several malignancies, including prostate cancer, where it acts as an oncogenic driver. Researchers are increasingly focused on understanding the molecular mechanisms by which ETV5 influences gene expression and cell behavior, as this knowledge may reveal potential therapeutic targets. The recombinant production of ETV5 protein has enabled detailed structural and functional studies, shedding light on its interaction with DNA and other proteins, and facilitating the development of inhibitors targeting ETV5's activity. As cancer research progresses, the study of ETV5 continues to unveil its dual role in normal physiology and pathogenesis, highlighting its potential as a biomarker and a strategic target for cancer treatment.
