Analytical Data
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Gene name
VANGL1
- Application
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Alternative Names
STB2; LPP2; Strabismus 2; Vang,Van Gogh-Like 1; Loop-tail protein 2 homolog
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q80Z96
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Expression Region
Val229~Gly469
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Molecular Weight
27kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VANGL1 (Vang-like 1) is a key protein involved in the regulation of planar cell polarity (PCP) and has garnered significant attention in developmental biology and disease research. PCP is a fundamental biological process that orients cells and tissues in a uniform manner, crucial for the development of various organs and structures, particularly in the nervous system. Aberrant regulation of VANGL1 has been implicated in several congenital disorders, such as neural tube defects and ciliopathies, due to its role in mediating signaling pathways that dictate cellular orientation and alignment. Additionally, VANGL1 has been linked to cancer progression, where its dysregulation may influence tumor cell morphology and metastatic behavior. The recombinant study of VANGL1 allows researchers to explore its structure-function relationship, interaction with other PCP components, and its role in signaling cascades at a molecular level. This research is essential for understanding VANGL1’s diverse functions in health and disease, paving the way for potential therapeutic targets in conditions arising from PCP dysregulation. The recombination techniques utilized to produce VANGL1 facilitate detailed investigations into its biological mechanisms, contributing to a broader understanding of PCP and its implications in developmental biology and oncology.
