Analytical Data
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基因名
NKX2-5
- Application
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别名
CSX; NKX2E; CSX1; NKX2.5; NKX4-1; Tinman Paralog; Cardiac-Specific Homeo Box; NK2 Transcription Factor Related Protein, Locus 5
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P52952
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表达区间
Gln24~Arg137
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分子量
16kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NKX2-5, a member of the NK-2 family of transcription factors, plays a crucial role in cardiac development and function. It is predominantly expressed in the heart, specifically during embryogenesis, where it regulates cardiac progenitor cell differentiation and the formation of the heart's structural components. Mutations or dysregulation of NKX2-5 are associated with various congenital heart defects and arrhythmias, making it a significant focus of research in cardiology and developmental biology. The study of NKX2-5 recombinant proteins has gained traction as a means to elucidate its functional mechanisms and interactions with other molecules involved in heart development. By creating recombinant NKX2-5 proteins, researchers can investigate the effects of specific domain mutations, assess protein-protein interactions, and explore their impacts on gene expression in vitro. Furthermore, understanding the structural biology of NKX2-5 offers insights into the molecular basis of its role in heart formation and its potential as a therapeutic target. Such research has implications not only for congenital heart disease but also for regenerative medicine and tissue engineering, as insights gained could inform approaches to repair or regenerate damaged heart tissue. Overall, the exploration of NKX2-5 recombinant proteins is pivotal for advancing our knowledge of cardiac biology and developing novel therapeutic strategies for heart-related disorders.
