Analytical Data
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Gene name
PSMD6
- Application
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Alternative Names
S10; p44S10; Rpn7; PFAAP4; 26S proteasome regulatory subunit RPN7; Breast cancer-associated protein SGA-113M; Phosphonoformate immuno-associated protein 4
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15008
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Expression Region
Met1~Met389
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Molecular Weight
76kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PSMD6, a crucial component of the 26S proteasome complex, plays a vital role in protein degradation and regulation within eukaryotic cells. As a regulatory particle, PSMD6 is involved in the recognition and unfolding of ubiquitinated substrates, facilitating their translocation into the catalytic core of the proteasome for proteolytic degradation. Research into PSMD6 has gained significance due to its implications in various cellular processes, including cell cycle regulation, apoptosis, and the modulation of signaling pathways. Dysregulation of proteasomal activity, in which PSMD6 is implicated, has been linked to several diseases, including cancer and neurodegenerative disorders. Thus, the characterization of PSMD6, especially in its recombinant form, is crucial for understanding its functional mechanisms and potential roles in disease. Advances in recombinant protein technologies allow for the production and purification of PSMD6, enabling detailed studies of its structure-function relationships. Investigating PSMD6's interactions with other proteasomal subunits and cellular factors can provide insights into the overall proteasome function and its impact on cell homeostasis. Overall, the study of PSMD6 recombinant protein not only enhances our understanding of proteasomal dynamics but also opens avenues for therapeutic interventions in diseases associated with proteostasis imbalance.
