Analytical Data
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Gene name
MPC1
- Application
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Alternative Names
CGI-129; BRP44L; Brain Protein 44 Like Protein
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5U8
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Expression Region
Met1~Ala109
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Molecular Weight
42kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MPC1 (Mitochondrial Pyruvate Carrier 1) is a crucial protein involved in the transport of pyruvate into mitochondria, a process vital for cellular metabolism and energy production. Understanding MPC1 is particularly significant in the context of metabolic diseases and cancer, where altered mitochondrial function and energy production pathways often play a critical role. Research has shown that MPC1 facilitates the entry of pyruvate into the mitochondria, thus linking glycolysis to the tricarboxylic acid (TCA) cycle. Mutations or reduced expression of MPC1 can lead to impaired mitochondrial metabolism, which has implications for conditions such as obesity, diabetes, and certain types of cancer, where tumor cells exhibit a preference for glycolysis over oxidative phosphorylation (the Warburg effect). As scientists continue to unravel the complexities of mitochondrial bioenergetics, the study of recombinant MPC1 proteins allows for a deeper understanding of its structural and functional properties. Investigating recombinant MPC1 can help clarify how pyruvate transport mechanisms influence energy balance within cells, possibly uncovering new therapeutic targets for metabolic disorders and cancer treatment. By harnessing advanced techniques in protein engineering and functional assays, researchers aim to elucidate the molecular underpinnings of MPC1 activity, thus contributing to the broader field of metabolic research and potential clinical applications.
