Analytical Data
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Gene name
CADM4/IGSF4C
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简介
CADM4/IGSF4C Protein is crucial for calcium- and magnesium-independent cell-cell adhesion, actively mediating cellular interactions. Apart from its adhesive role, it is speculated to act as a tumor suppressor, hinting at a potential regulatory role in cell growth and tumorigenic processes. The dual attributes of mediating adhesion and potentially suppressing tumors highlight the multifaceted nature of CADM4/IGSF4C in cellular processes. CADM4/IGSF4C Protein, Human (HEK293, His) is the recombinant human-derived CADM4/IGSF4C protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Biological Activity
Measured by its ability to inhibit the proliferation of A549 cells. The ED50 for this effect is 0.4653 μg/mL, corresponding to a specific activity is 2.149×103 units/mg. Measured by its ability to inhibit the proliferation of A549 cells. The ED50 for this effect is 0.4653 μg/mL, corresponding to a specific activity is 2.149×103 units/mg.
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Alternative Names
Cell adhesion molecule 4; NECL-4; IGSF4C; TSLL2
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q8NFZ8
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Expression Region
P21-Y323
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AA Sequence
PGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPY
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Protein Length
Extracellular Domain
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Molecular Weight
48-70 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CADM4 (Cell Adhesion Molecule 4) and IGSF4C (Immunoglobulin Superfamily Member 4C) are two cell adhesion molecules that share structural similarities and play crucial roles in synapse formation and maintenance in the nervous system. Both proteins are involved in cell-cell interactions, influencing neuronal connectivity and plasticity. Their dysfunction has been associated with various neurological disorders, including schizophrenia and autism spectrum disorders. Recent studies have highlighted the importance of understanding the molecular mechanisms governing the interactions mediated by CADM4 and IGSF4C, as they may reveal novel therapeutic targets for these conditions. The recombinant proteins of CADM4 and IGSF4C are essential for elucidating their functional properties, as they allow researchers to study their interactions in controlled environments. By producing these proteins through recombinant DNA technology, researchers can investigate their binding affinities, structural configurations, and signaling pathways, providing insights into how these adhesion molecules modulate neural circuit development and function. This research is vital for advancing our understanding of the molecular basis of synaptic disorders and could lead to innovative strategies for treatment.
