Analytical Data
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Gene name
LAMP5/BAD-LAMP
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简介
LAMP5/BAD-LAMP protein plays a role in short-term synaptic plasticity within a specific subset of GABAergic neurons in the brain. LAMP5/BAD-LAMP Protein, Human (HEK293, His) is the recombinant human-derived LAMP5/BAD-LAMP protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
BAD-LAMP; LAMP-5; BADLAMP; C20orf103; dJ1119D9.3; UNC-43
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Species
Human
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UJQ1-1
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Expression Region
E30-E235
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Protein Length
Extracellular Domain
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Molecular Weight
30-40 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The LAMP5 (Lysosome-associated membrane protein 5) and BAD-LAMP (B-cell activation determinant-LAMP) recombinant proteins have garnered significant attention in immunology and cell biology research. Both proteins are members of the LAMP family, characterized by their role in lysosomal stability, endosomal trafficking, and immune responses. The LAMP5 protein, primarily expressed in neural tissues and immune cells, plays a crucial role in the immune system, particularly in antigen presentation and T cell activation. In contrast, BAD-LAMP is a specialized form associated primarily with B cells and is believed to participate in the maturation of B cell responses and the regulation of antibody production. The study of these recombinant proteins has the potential to elucidate their functional roles in various pathological conditions, including autoimmune diseases and cancers. By harnessing the unique properties of LAMP5 and BAD-LAMP, researchers aim to develop targeted therapies and diagnostic tools that capitalize on their functions in cellular immunity. The advancement of recombinant DNA technology facilitates the production of these proteins in sufficient quantities, enabling detailed biochemical and structural analyses that could lead to novel insights into their mechanisms of action and interactions within cellular contexts. As the understanding of LAMP5 and BAD-LAMP continues to evolve, it holds promise for uncovering therapeutic avenues for enhancing immune responses or modulating excessive immune activity in disease states.
