Analytical Data
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基因名
TBC1D13
- Application
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NVG8
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表达区间
Met1~Asp345
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分子量
44kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBC1D13 is a member of the TBC (Tre-2/Bub2/CDC16) family of proteins, which are known to be involved in the regulation of small GTPases like Rab proteins, playing a significant role in intracellular transport processes. Research has identified TBC1D13 as a critical regulator of vesicle trafficking, particularly in endosomal and lysosomal pathways. Its ability to act as a GTPase-activating protein (GAP) for Rab proteins suggests it has a hand in modulating various cellular functions, including protein sorting, membrane fusion, and cellular signaling. Disruptions in TBC1D13 function have been linked to several pathologies, including neurodegenerative diseases and cancer, making it a potential target for therapeutic interventions. Moreover, TBC1D13 has been shown to interact with various cellular partners, thereby influencing diverse cellular processes beyond vesicle trafficking. The investigation into TBC1D13 not only enhances our understanding of the molecular mechanisms underlying these diseases but also sheds light on the broader implications of Rab GTPase regulation in maintaining cellular homeostasis. Therefore, this protein has emerged as a focal point in cell biology, with ongoing studies exploring its structural properties, interaction networks, and functional roles in health and disease. Enhanced knowledge of TBC1D13 could provide significant insights into developing novel treatments for related disorders.
