Analytical Data
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基因名
Histone chaperone ASF1A/ASF1A
- Application
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别名
Anti-silencing function protein 1 homolog A
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y294
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表达区间
1-204aa
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分子量
50 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Histone chaperones play a critical role in the dynamic regulation of chromatin, facilitating the assembly and disassembly of histone proteins during processes such as DNA replication, repair, and transcription. ASF1A (Anti-Silencing Function 1A) is a key histone chaperone that interacts with histones H3 and H4, assisting in their deposition onto DNA and regulating their post-translational modifications. The study of ASF1A is vital because alterations in histone dynamics can lead to epigenetic changes associated with various diseases, including cancer. Understanding the molecular mechanisms underlying ASF1A's function can provide insights into chromatin remodeling and cellular differentiation processes. Additionally, researchers have been focusing on the potential of ASF1A as a therapeutic target due to its role in maintaining genome stability. Recombination of ASF1A protein allows for the exploration of its structure-function relationship, aiding in the identification of its binding partners and elucidating its role in histone modifications. Overall, ASF1A represents a promising avenue for further investigation in the field of epigenetics, with implications for development and disease modulation.
