Analytical Data
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Gene name
C5AR2
- Application
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Alternative Names
Complement component 5a receptor 2 G-protein coupled receptor 77 C5L2, GPR77
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Species
Human
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Source
E. coli
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9P296
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Expression Region
1-337aa
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Molecular Weight
38.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C5a receptor 2 (C5AR2) is a member of the G protein-coupled receptor family and plays a crucial role in the immune response. This receptor is mainly involved in the regulation of inflammation and the modulation of immune cell activities, particularly in response to the anaphylatoxin C5a, a product of the complement system. Elevated levels of C5a have been associated with various pathological conditions, including autoimmune diseases, sepsis, and chronic inflammatory disorders. Unlike its counterpart C5a receptor 1 (C5AR1), which primarily mediates pro-inflammatory responses, C5AR2 has been shown to exhibit anti-inflammatory properties, making it an intriguing target for therapeutic interventions. Studies have indicated that C5AR2 can influence the recruitment and activation of immune cells, thereby altering the course of inflammatory responses. Understanding the distinct signaling pathways and biological functions of C5AR2 is essential for elucidating its role in health and disease. Recent research has focused on the structural characterization of C5AR2 through recombinant protein technology, enabling the study of its interaction with ligands and potential inhibitors. This work aims to provide insights into the receptor's therapeutic potential, particularly in developing novel treatments for conditions where the complement system and inflammation play pivotal roles. The exploration of C5AR2 as a drug target represents a promising avenue in the quest for effective therapies for immune-related diseases.
