Analytical Data
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基因名
CENPK
- Application
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别名
Interphase centromere complex protein 37 Protein AF-5alpha p33
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BS16
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表达区间
1-269aa
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分子量
58.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CENPK, or Centromere Protein K, is a pivotal player in the assembly and function of kinetochores, which are essential structures for chromosome segregation during cell division. It is crucial for maintaining genomic stability and proper cell cycle progression. Recent studies have highlighted CENPK's role in various cellular processes, including DNA repair and the response to oncogenic stress, making it a significant focus in cancer research. The recombinant production of CENPK protein is vital for elucidating its biochemical properties and cellular functions. By employing techniques like recombinant DNA technology and protein expression systems, researchers aim to obtain high-purity CENPK for functional assays, structural studies, and potential therapeutic applications. Investigating the interactions of CENPK with other kinetochore components and regulatory proteins could provide insights into its mechanistic roles and uncover novel targets for cancer treatment. Thus, understanding CENPK through recombinant technology not only contributes to basic biological knowledge but also holds promise for the development of innovative therapeutic strategies against diseases characterized by chromosomal instability.
