Analytical Data
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Gene name
DIRAS3
- Application
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Alternative Names
Distinct subgroup of the Ras family member 3 Rho-related GTP-binding protein RhoI
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95661
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Expression Region
1-229aa
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Molecular Weight
52.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DIRAS3 (DIRAS Family GTPase 3) is a member of the DIRAS family of GTPases, which play crucial roles in various cellular processes, including cell proliferation, differentiation, and survival. Research has shown that DIRAS3 is primarily expressed in the human placenta and certain tissues, suggesting its potential involvement in reproductive biology and developmental processes. Notably, DIRAS3 has gained attention for its tumor suppressor functions, as its downregulation or loss is frequently observed in various cancers, including breast, ovarian, and lung cancers. Studies have indicated that DIRAS3 may inhibit tumor growth and promote apoptosis, making it a significant biomarker for cancer progression and a potential target for therapeutic strategies. Its unique structure, characterized by a GTP-binding domain, positions DIRAS3 as a pivotal player in the regulation of signaling pathways often altered in malignancies. The recombinant expression of DIRAS3 protein allows for in-depth studies on its biochemical properties, interactions with other cellular molecules, and its functional role in cancer biology. Understanding DIRAS3 at the molecular level may reveal insights into its mechanistic role in tumor suppression and pave the way for novel treatment modalities aimed at reactivating its function in cancerous cells. Thus, the research surrounding DIRAS3 recombinant protein is crucial for elucidating its biological significance and therapeutic potential in oncology.
