Analytical Data
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基因名
DCTN6
- Application
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别名
Dynactin subunit p27 Protein WS-3
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00399
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表达区间
1-190aa
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分子量
47.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DCTN6, or Dynactin subunit 6, is a key component of the dynactin complex, which plays a crucial role in cellular transport and the regulation of organelle movement within neurons. Research into DCTN6 has gained significant attention due to its involvement in various neurodegenerative diseases and its essential function in mediating the interaction between dynein motor proteins and cellular cargo. Dysregulation of DCTN6 is associated with conditions such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease, where inefficient transport of organelles and proteins contributes to neuronal degeneration. The study of recombined DCTN6 proteins helps elucidate their structural and functional properties, providing insights into the molecular mechanisms underlying cellular transport. By utilizing recombinant protein techniques, researchers can investigate the interactions of DCTN6 with other cellular components, assess its functional abilities in vitro, and explore potential therapeutic targets. Understanding the role of DCTN6 in the dynactin complex could offer new avenues for interventions aimed at mitigating the impact of neurodegenerative diseases, making it a vital area of research in the field of cell biology and neuroscience.
