Analytical Data
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Gene name
DNAJB2
- Application
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Alternative Names
DnaJ protein homolog 1Heat shock 40KDA protein 3Heat shock protein J1 ;HSJ-1
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P25686
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Expression Region
2-324aa
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Molecular Weight
51.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DNAJB2 is a member of the DnaJ heat shock protein family, which plays a crucial role in protein folding, stabilization, and degradation processes, particularly under stress conditions. Recent studies have highlighted the significance of DNAJB2 in neurodegenerative diseases, cancer, and other cellular stress responses. The protein is known to interact with various chaperones and substrates, facilitating the proper folding of nascent polypeptides and the refolding of misfolded proteins. This has made DNAJB2 a subject of interest in understanding the underlying mechanisms of cellular stress response and disease pathology. However, its specific biochemical properties and functional implications remain inadequately explored. The recombinant expression of DNAJB2 in various systems provides a valuable tool for elucidating its molecular mechanisms and potential therapeutic applications. By generating and characterizing DNAJB2 recombinant proteins, researchers aim to investigate the role of DNAJB2 in the cellular stress response and its involvement in various disease pathways, paving the way for potential innovations in targeted therapies and drug development. Understanding the structure-function relationship of DNAJB2 through recombinant studies may also reveal novel insights into its regulatory mechanisms and interactions within the cellular environment.
