Analytical Data
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基因名
ETHE1
- Application
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别名
Ethylmalonic encephalopathy protein 1Hepatoma subtracted clone one protein;Sulfur dioxygenase ETHE1
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95571
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表达区间
8-254aa
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分子量
43.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ETHE1 is a protein associated with the human mitochondrial sulfur metabolic pathway, playing a crucial role in maintaining cellular redox homeostasis. Mutations in the ETHE1 gene have been linked to a rare autosomal recessive disorder known as ethylmalonic encephalopathy, which is characterized by neurological dysfunction, short stature, and metabolic abnormalities. Research into ETHE1 has gained significance due to its involvement in hydrogen sulfide metabolism and mitochondrial function, which are essential for energy production and detoxification processes within cells. Recent studies have focused on understanding the structural and functional properties of the ETHE1 protein, revealing insights into its enzymatic mechanisms and interactions with other cellular components. This research is vital not only for elucidating the pathophysiology of related disorders but also for developing potential therapeutic strategies aimed at alleviating symptoms associated with ETHE1 dysfunction. By investigating the dynamics of ETHE1, scientists aim to enhance our comprehension of mitochondrial diseases and contribute to the broader field of metabolic research, potentially leading to novel interventions for patients suffering from mitochondrial disorders.
