Analytical Data
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Gene name
Fcmr
- Application
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Alternative Names
Regulator of Fas-induced apoptosis Toso
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Species
Mouse
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A1KXC4
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Expression Region
18-262aa
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Molecular Weight
43.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FCMR (Fcgamma receptor, mixed) is a crucial component in the immune response, primarily involved in regulating antibody-mediated functions and modulating inflammation. It belongs to the family of Fc receptors, which bind the Fc region of antibodies, thus playing a significant role in effector functions such as phagocytosis, antibody-dependent cellular cytotoxicity, and the activation of immune cells like macrophages and dendritic cells. Recent studies have highlighted FCMR's unique ability to interact with different antibody isotypes, underscoring its potential in influencing immune responses during infections and in autoimmune diseases. The research into recombinantly produced FCMR proteins aims to elucidate its structural and functional properties, enabling a deeper understanding of its role in health and disease. These studies potentially pave the way for new therapeutic strategies targeting FCMR to modulate immune responses, providing opportunities for novel treatments in conditions such as cancer, chronic inflammation, and infectious diseases. As the field of immunology evolves, the characterization and manipulation of FCMR through recombinant protein technology hold promise for advancing immune-based therapies and enhancing our overall understanding of immune regulation.
