Analytical Data
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Gene name
CCR6
- Application
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Alternative Names
Chemokine receptor-like 3 (CKR-L3) (DRY6) (G-protein coupled receptor 29) (GPR-CY4) (GPRCY4) (LARC receptor)
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Species
Human
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P51684
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Expression Region
1-47aa
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Molecular Weight
12.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCR6 (C-C chemokine receptor type 6) is a chemokine receptor primarily expressed on immune cells, including T-helper 17 (Th17) cells, and plays a crucial role in inflammatory responses and autoimmune diseases. Research on CCR6 has garnered significant attention due to its involvement in various pathological conditions, such as multiple sclerosis, rheumatoid arthritis, and certain cancers. The receptor’s interaction with its ligand CCL20 is pivotal for the migration and retention of immune cells in inflammatory sites. Therefore, studying CCR6 and developing recombinant CCR6 proteins can provide valuable insights into its biological functions and mechanisms of action. Such recombinant proteins can serve as important tools for investigating receptor signaling pathways, understanding immune cell trafficking, and exploring potential therapeutic targets. Furthermore, CCR6 has emerged as a candidate for immunotherapeutic approaches, making it essential to comprehend its structural and functional characteristics. Progress in CCR6 research may lead to novel strategies for modulating immune responses, highlighting the importance of this receptor in both basic and applied immunology. Overall, the study of CCR6 and its recombinant proteins is critical for delineating its role in immune regulation and developing interventions for immune-mediated diseases.
