Analytical Data
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Gene name
FBXW4
- Application
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Alternative Names
Dactylin F-box and WD-40 domain-containing protein 4
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P57775
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Expression Region
1-412aa
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Molecular Weight
62.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FBXW4 is a member of the F-box protein family, which plays a crucial role in the ubiquitin-proteasome system by mediating protein degradation. Recent studies have highlighted FBXW4's involvement in various biological processes, including cell cycle regulation, cellular apoptosis, and development. Dysregulation of FBXW4 has been linked to several diseases, including cancer, where it may influence tumor progression and metastasis through its regulatory functions. Research on FBXW4 has gained momentum as scientists seek to understand its specific mechanisms of action, interactions with other proteins, and potential as a therapeutic target. Understanding FBXW4's role in cellular homeostasis and its implications in disease could provide insights into novel treatment strategies and enhance our knowledge of the ubiquitin-mediated degradation pathways. Given the importance of protein turnover in maintaining cellular function, exploring FBXW4 and its interactions is crucial for both basic biology and therapeutic advancements.
