Analytical Data
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基因名
GNPDA1
- Application
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别名
Glucosamine-6-phosphate deaminase 1 ;GNPDA 1 ;GlcN6P deaminase 1Oscillin
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P46926
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表达区间
1-289aa
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分子量
36.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNPDA1 (Glucosamine-6-phosphate deaminase 1) is an enzyme that plays a pivotal role in amino sugar metabolism and is crucial for maintaining cellular glucose homeostasis. Recent studies have highlighted its involvement in various biological processes, including the regulation of insulin signaling and potential links to metabolic disorders such as obesity and type 2 diabetes. GNPDA1's function in the conversion of glucosamine-6-phosphate to fructosamine-6-phosphate makes it essential for the proper functioning of the hexosamine biosynthetic pathway, which is critical for post-translational modifications of proteins. Furthermore, genetic variations in the GNPDA1 gene have been associated with increased susceptibility to metabolic diseases, making it a significant target for therapeutic interventions. Research into recombinant GNPDA1 protein aims to elucidate its structural properties and enzymatic mechanisms, potentially leading to the development of novel treatments for metabolic disorders. By producing and characterizing this recombinant protein, scientists can better understand its role in cellular metabolism and explore its potential as a biomarker or therapeutic target in metabolic syndrome and related diseases.
